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using System.Runtime.InteropServices;
[DllImport("User32.dll", CharSet = CharSet.Auto)]
public static extern int GetWindowThreadProcessId(IntPtr hwnd, out int ID);
protected void Button1_Click(object sender, EventArgs e)
{
Excel.ApplicationClass myExcel= new Microsoft.Office.Interop.Excel.ApplicationClass();
excel.Workbooks.Open("d:\aaa.xls", Type.Missing, Type.Missing, Type.Missing, Type.Missing, Type.Missing, Type.Missing, Type.Missing, Type.Missing, Type.Missing, Type.Missing, Type.Missing, Type.Missing, Type.Missing, Type.Missing);
IntPtr t = new IntPtr(myExcel.Hwnd);
int k = 0;
GetWindowThreadProcessId(t, out k);
System.Diagnostics.Process p = System.Diagnostics.Process.GetProcessById(k);
p.Kill();
}