IIS6 Event code: 3005

[707397107]

这段时间，服务器日志中总会报警告：Event code: 3005 。
而且，IIS服务有时会用不了，要重启IIS服务才能用。
请问这是什么原因？有啥解决方案没？
下面是日志的详细信息：
Event code: 3005
Event message: 发生了未经处理的异常。
Event time: 2017/6/14 13:10:16
Event time (UTC): 2017/6/14 5:10:16
Event ID: ac84b89c10b2403596e037ac260f0eed
Event sequence: 797
Event occurrence: 397
Event detail code: 0

Application information:
Application domain: /LM/W3SVC/7/ROOT-1-131418881443657711
Trust level: Full
Application Virtual Path: /
Application Path: D:\WEB\ZXYY_Microsite\
Machine name: WIN-HGMFV9RA3C9

Process information:
Process ID: 1468
Process name: w3wp.exe
Account name: IIS APPPOOL\Microsite

Exception information:
Exception type: TargetInvocationException
Exception message: 调用的目标发生了异常。
在 System.RuntimeTypeHandle.CreateInstance(RuntimeType type, Boolean publicOnly, Boolean noCheck, Boolean& canBeCached, RuntimeMethodHandleInternal& ctor, Boolean& bNeedSecurityCheck)
在 System.RuntimeType.CreateInstanceSlow(Boolean publicOnly, Boolean skipCheckThis, Boolean fillCache, StackCrawlMark& stackMark)
在 System.RuntimeType.CreateInstanceDefaultCtor(Boolean publicOnly, Boolean skipCheckThis, Boolean fillCache, StackCrawlMark& stackMark)
在 System.Activator.CreateInstance(Type type, Boolean nonPublic)
在 System.Activator.CreateInstance(Type type)
在 System.Web.Mvc.DefaultControllerFactory.DefaultControllerActivator.Create(RequestContext requestContext, Type controllerType)

远程服务器返回错误: (500) 内部服务器错误。
在 CoreFrame.Common.WebApiHelper.Submit(String url, RequestType type, String postData)
在 CoreFrame.Common.SignHelper.GetToken(String serviceUrl, String getTokenUrl, String request, String account, String key)
在 GWI.ServiceShell.PHRService.CallPHR[TRequest,TReponse](Request`1 PHRRequest)
在 GWI.MicroSite.Controllers.MicroSiteController..ctor()
在 GWI.MicroSite.Controllers.RegisterController..ctor()



Request information:
Request URL: http://phr.gwi.com.cn:7779/Register/AliPayRegister?app_id=2014112400017449&source=alipay_wallet&scope=auth_userinfo&auth_code=622a86f74b8f459eb035daed4ce7SB02
Request path: /Register/AliPayRegister
User host address: 203.209.232.95
User:
Is authenticated: False
Authentication Type:
Thread account name: IIS APPPOOL\Microsite

Thread information:
Thread ID: 1353
Thread account name: IIS APPPOOL\Microsite
Is impersonating: False
Stack trace: 在 System.RuntimeTypeHandle.CreateInstance(RuntimeType type, Boolean publicOnly, Boolean noCheck, Boolean& canBeCached, RuntimeMethodHandleInternal& ctor, Boolean& bNeedSecurityCheck)
在 System.RuntimeType.CreateInstanceSlow(Boolean publicOnly, Boolean skipCheckThis, Boolean fillCache, StackCrawlMark& stackMark)
在 System.RuntimeType.CreateInstanceDefaultCtor(Boolean publicOnly, Boolean skipCheckThis, Boolean fillCache, StackCrawlMark& stackMark)
在 System.Activator.CreateInstance(Type type, Boolean nonPublic)
在 System.Activator.CreateInstance(Type type)
在 System.Web.Mvc.DefaultControllerFactory.DefaultControllerActivator.Create(RequestContext requestContext, Type controllerType)


Custom event details: