可以的
// Regex match
RegexOptions options = RegexOptions.None;
Regex regex = new Regex(@"^[^a-zA-Z]+|^[a-z]+[^a-z_A-Z]+$", options);
string input = @"abcab&#";
// Check for match
bool isMatch = regex.IsMatch(input);
if( isMatch )
{
// TODO: Do something with result
System.Windows.Forms.MessageBox.Show(input, "IsMatch");
}